Darlington Road, Main Street
- Southern Terminus:
- Level Road (MD 155) in Havre de Grace
- Northern Terminus:
- Conowingo Road (US 1) in Darlington
- 5.38 miles
MD 161 is a short north/south route extending from Level Road (MD 155) to Conowingo Road (US 1). It is known as Darlington Road for much of its length but changes names to become Main Street in Darlington.