- Southern Terminus:
- Solomons Island Road (MD 4) and Southern Maryland Boulevard (MD 4) in Huntingtown
- Northern Terminus:
- North Avenue (US 1) in Baltimore
- 79.24 miles
- Calvert, Anne Arundel
- Independent Cities:
MD 2 is a north/south route connecting Southern Maryland to Baltimore. Solomons Island Road splits off from MD 4 to become MD 2 in Huntingtown and runs north to John Hanson Highway (US 50). The two routes are multiplexed for a couple of exits, and then MD 2 splits off to become Governor Ritchie Highway, a large four-lane divided highway that runs north to Baltimore. At the city line, Governor Ritchie Highway ends, and MD 2 follows Potee Street, Hanover Street, West Montgomery Street, Light Street, and Calvert Street through the city, ultimately ending at North Avenue (US 1).