- Southern Terminus:
- Pylesville Road (MD 165) at the Maryland-Pennsylvania state line
- Northern Terminus:
- PA 75 in Port Royal
- 93.14 miles
- York, Cumberland, Perry, Juniata
PA 74 is a north/south route running diagonally through the southern central area of Pennsylvania. Pylesville Road (MD 165) becomes PA 74 upon entering the state from Maryland. It runs northwest, passing through York and Carlisle and then through the mountains to end at PA 75 in Port Royal.